Symposium

5/12 (Mon) 8:30-10:30 A+B

International Symposium 1
Mitochondria, Protein homeostasis and Cell Death

Chair

Derek Hausenloy, Kinya Otsu

• 
  Unifying Cell Death Programs in Myocardial Infarction

  Richard Kitsis
• 
  Targeting the JAK1-STAT3 pathway to treat cardiac proteinopathy

  Sonia Singh
• 
  Extracellular Vesicles and Cellular Quality Control Mechanisms in Cardioprotection

  Asa Gustafsson
• 
  Mitochondrial Shape, Autophagy, and Heart Failure: a Triad to Combat.

  Luca Scorrano
• 
  Role of lipid phosphate phosphatases in cardiac energy metabolism and function

  Petra Kienesberger
• 
  ND-13 confers cardioprotection by inhibiting mitochondrial fission and preserving mitochondrial bioenergetics via the RhoA-ROCK1-Drp1

  Sauri Hernandez

5/12 (Mon) 8:30-10:30 201+202

International Symposium 2
New mechanisms to protect against heart failure with preserved ejection fraction

Chair

David Lefer, Sean Davidson

• 
  Targeting Class IIa HDAC signaling in cardiometabolic disease

  Johannes Backs
• 
  Cyclic GMP as a therapeutic target for HFpEF

  Rebecca Ritchie
• 
  Trans-differentiation of cardiac fibroblasts reveals a new molecular mechanisms for HfpEF

  Taketaro Sadahiro
• 
  Tyrosine kinase phosphorylation of troponin I is a novel mechanism to increase myocardial relaxation

  Brandon Biesiadecki
• 
  Unique immunometabolic treatment strategies to protect against HFpEF

  Judy de Haan
• awaiting
  PCSK5 Promotes Angiogenesis and Cardiac Repair After Myocardial Infarction

  Dan Meng

5/12 (Mon) 8:30-10:30 203

International Symposium 3
Interorgan communications in heart failure

Chair

Doan Ngo, Yu Ying

• 
  Multi-organ cross-talk via innate immune memory in heart failure

  Yukiteru Nakayama
• 
  Liver/adipose tissue-Heart cross talk in HFpEF and Cardiometabolic disease

  Gabriele Schiattarella
• 
  Hematopoietic mutations and cardiac fibrosis

  Stefanie Dimmeler
• 
  Immune checkpoint signaling and heart failure

  Zoltan Varga
• 
  Brain-heart cross talk in HF

  Daniela Carnevale
• 
  Deletion of Piezo1 in adult cardiomyocytes accelerates cardiac senescence and causes premature death

  Jane Yu

5/12 (Mon) 16:05-18:05 A+B

International Symposium 4
Shaping the cardiac proteome in health and disease

Chair

Lucie Carrier, Ying Ge

• 
  Regulation of the cardiac translatome

  Yibin Wang
• 
  Myosin S2 and cMyBP-C Interactions in Cardiac Function and Hypertrophic Cardiomyopathy

  Sakthivel Sadayappan
• 
  The unfolded protein response and ER stress

  Shirin Doroudgar
• 
  Proteostasis regulation by the multi-tRNA synthetase complex

  Federica Accornero
• 
  Proteostasis in hypertrophic cardiomyopathy

  Diederik Kuster
• 
  CAMK2D underlies cardiac dysfunction in RBM20 cardiomyopathy

  Maarten van den Hoogenhof

5/12 (Mon) 16:05-18:05 201+202

International Symposium 5
E-C Coupling: channels, regulators and key players

Chair

Ana-Maria Gomez, Yoshihiko Saito

• 
  Endoplasmic reticulum stress and excitation-contraction coupling machinery

  Marek Michalak
• 
  Junctophilin-2 Regulation of Cardiac E-C Coupling and Transcription

  Long-Sheng Song
• 
  GRK2 regulation of beta-adrenergic signaling and Ca2+ handling in the heart

  Shi-Qiang Wang
• 
  S-Nitrosylation of CaMKII and cardiac arrhythmia

  Jeffrey Erikson
• 
  IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression

  Emiliano Medei
• awaiting
  PEGylated isoprenaline reveals distinct functions of cardiac β-adrenergic receptors located in the T-tubule vs. outer surface membrane

  George Madders

5/12 (Mon) 16:05-18:05 203

International Symposium 6
Regulation of endogenous cardiac regeneration

Chair

Lena Ho, Florian Weinberger

• 
  RNA therapies for cardiac regeneration

  Mauro Giacca
• 
  Advancing Cardiac Therapeutics

  Eldad Tzahor
• 
  Creating a repair permissive heart

  Eva van Rooij
• 
  A switch in cardiac fibroblasts hinders regeneration after neonatal myocardial infarction

  Diana Nascimento
• 
  Modulating cell polarity to promote cardiomyocyte regeneration

  Caitlin C. O'Meara
• 
  Ventricular crosstalk activates regenerative mechanisms in the contralateral ventricle in neonatal mice

  Mona Malek Mohammadi

5/13 (Tue) 8:15-10:15 A+B

International Symposium 7
New players in mitochondrial calcium regulation

Chair

Lea Delbridge, Yi Zhu

• 
  Manipulating the L-type calcium channel to alter mitochondrial function in diastolic heart disease

  Livia Hool
• 
  TMEM65 controls mitochondrial Ca2+ extrusion

  Diego De Stefani
• 
  Targeting mitochondrial ROS formation in cardiac pathology

  Nina Kaludercic
• 
  Reticulum-Mitochondria Ca2+ Coupling in Metabolic HFpEF: A Liver-Heart Crosstalk

  Melanie Paillard
• 
  A new facet of myocardial necroptosis: crosstalk with mitochondrial dynamics and autophagy

  Toshiyuki Yano
• 
  A porcine model of prolonged cardiac arrest and extracorporeal membrane oxygenation following myocardial infarction. A Pilot Feasibility Study

  Candice Todd

5/13 (Tue) 8:15-10:15 201+202

International Symposium 8
Health and Disease Mechanisms of Women’s Heart

Chair

Lorrie Kirshenbaum, Kika Sucharov

• 
  The cardiac pathophysiological outcomes of shift work during pregnancy

  Inna Rabinovich-Nikitin
• 
  Cardiovascular (reverse) remodeling induced by pregnancy

  Ana Filipa Ferreira
• 
  Proteogenomic insights into dimorphic exon usage in aging hearts

  Maggie Lam
• 
  Heart failure with preserved ejection fraction in humans and mice: what does sex have to do with it?

  Rudolf de Boer
• 
  Sex differences in cardiac electrophysiology and drug response

  Raffaele Coppini
• 
  Sex differences in left ventricular recovery and corresponding gene expression in a rat model of cardiac donation after circulatory death

  Anja Helmer

5/13 (Tue) 8:15-10:15 203

International Symposium 9
Cardiac Hippo-YAP signaling

Chair

Metin Avkiran, Emilio Hirsch

• 
  Phosphoproteomic deconvolution of signaling pathways controlling cardiomyocyte proliferation

  Enzo Porrello
• 
  Targeting Hippo-YAP signaling in heart failure

  James Martin
• 
  Beta adrenergic and YAP crosstalk regulate cardiomyocyte proliferation

  Mei Xin
• 
  The role of YAP in cardiac fibrosis

  Dominic Del Re
• awaiting
  Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes

  Ichiro Shiojima
• 
  Investigating the role of an orphan nuclear receptor NR4A1 in atrial fibrillation

  Kendrick Yiu

5/13 (Tue) 14:50-16:50 A+B

International Symposium 10
Modulators of cell-cell communication in heart failure

Chair

Don Bers, Susmita Sahoo

• 
  Crosstalk between adipose tissue and the heart in atrial fibrillation

  Paula Longhi
• 
  Impact of heart-derived factors from the protected and failing heart

  Julie McMullen
• 
  Macrophages as protectors of mitochondrial quality in the heart and beyond

  Nicolas Avila Jose Angel
• 
  Exercise-induced interorgan communication

  Kristin Stanford
• 
  Innate immune memory and organ cross-talk in heart failure

  Ichiro Manabe
• 
  Proteomics of hypertrophic cardiomyopathy extracellular vesicles elucidates detrimental effects of in vitro HCM cardiomyocyte secretome on endothelial cells and cardiomyocytes

  Sarah Hilderink

5/13 (Tue) 14:50-16:50 201+202

International Symposium 11
Spatial organization of protein synthesis in the myocardium

Chair

Llewelyn Roderick, Tim Kamp

• 
  The tubulin code as spatial regulator - what we can learn from the brain and the use of cell-free systems

  Marie-Jo Moutin
• 
  Localized protein translation in the heart

  Izhak Kehat
• 
  Microtubule-mediated spatial control: directing translation and remodeling in the myocardium

  Benjamin L. Prosser
• 
  Coordinated cotranslational association of ion channels mRNA in the heart

  Gail A. Robertson
• 
  Beta 1 and beta 2 receptor translation dynamics in healthy and failing heart

  Julia Gorelik
• awaiting
  Blood-based Protein Markers Associated with Myocardial Interstitial Fibrosis

  Leonoor Wijdeveld

5/13 (Tue) 14:50-16:50 203

International Symposium 12
Mechanistic insights of the role of impaired cardiac metabolism in driving heart failure

Chair

Yasuchika Takeishi, Junjie Xiao

• 
  Mechano-energetic uncoupling in HFrEF and HFpEF

  Christoph Maack
• 
  Mitochondrial crystae dynamics in the aging heart

  Verónica Eisner
• 
  New mechanistic insights into cardiac fibrosis and heart failure in diabetes emerging from cutting-edge computational biology and single-cell omics

  Alexander Pinto
• 
  Doxorubicin Damages the Heart Inducing Metabolic Rewiring: a Multi-Omics Journey Through Anthracycline Cardiotoxicity

  Giulia Guerra
• 
  Heart Failure in a Dish: Empagliflozin's Metabolic and Contractile Benefits in Patient Derived iPSC Cardiac Models

  Chrishan Ramachandra
• 
  Mitochondrial bioenergetics and ATP synthase

  Abraham Méndez Fernández

5/13 (Tue) 17:05-19:05 A+B

International Symposium 13
Regulatory mechanisms of intracellular Ca2+ signalling and excitability via intracellular organelle cross-talk

Chair

Gerardo Garcia-Rivas, Michelle Munro

• 
  RyR2 as an antiarrhythmic drug target

  Bjorn C. Knollmann
• 
  Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in ARVC

  Mario Delmar
• 
  Critical role of mitochondrial remodeling in cardiac arrhythmia

  Deli Zhang
• 
  Impact of Ca2+ crosstalk between mitochondria and sarcoplasmic reticulum in cardiomyocyte during workload transition

  Ayako Takeuchi
• 
  Critical role of NRSF-GNAO1 pathway in regulating Ca2+ signaling in ventricular myocytes

  Hideaki Inazumi
• 
  Adaptation to mitochondrial calcium overload varies between left and right ventricles

  Shanmugasundaram Pakkiriswami

5/13 (Tue) 17:05-19:05 201+202

International Symposium 14
Drug targets in Heart Failure

Chair

Walter J Koch, Lauren May

• 
  Targeting CAMKII to mend the failing heart

  Simon Lebek
• 
  HDACs as target for therapy in heart failure

  Tim McKinsey
• 
  Treating heart failure with novel REV-ERB agonist

  Lilei Zhang
• 
  GRK2 and Cardio-metabolic signaling in Heart Failure

  Priscila Sato
• 
  Development of genome editing tools based on deep mutational scanning

  Atsushi Hoshino
• 
  Targeting HDAC11 to reverse obesity and metabolic dysfunction in mice

  Marion Delaunay

5/13 (Tue) 17:05-19:05 203

International Symposium 15
Targeting metabolism to prevent heart failure progression: HFrEF vs HFpEF

Chair

Joan Heller Brown, Yumiko Oishi

• 
  Myocardial proteome defines the continuum in human HFpEF

  Jenny van Eyk
• 
  Mitochondria in HFpEF

  Rong Tian
• 
  Targeting glucose-derived O-GlcNAcylation pathway in heart failure

  Luc Bertrand
• 
  Targeting nicotinamide adenine dinucleotide for the treatment of HFpEF

  Mahmoud Abdellatif
• 
  The protective role of exercise on children metabolic syndrome

  Ming Xu
• 
  One Carbon Metabolism Defect In Human Failing Hearts

  Jae Woo Jung

5/14 (Wed) 8:15-10:15 A+B

International Symposium 16
Non-Myocyte Contributors to Arrhythmia

Chair

Bianca Brundel, Karin Sipido

• 
  Cardiac adiposity and arrhythmias

  Jim Bell
• 
  Fibroblasts regulate cardiac excitability and arrhythmogenesis

  Arjun Deb
• 
  Exploring the role of neuronal dysfunction in inherited arrhythmia syndromes

  Molly O'Reilly
• 
  Fibroblast-Myocyte interactions and their impact on cardiac electrophysiology

  Patrizia Camelliti
• 
  Macrophages and Electrical conduction in the Heart

  Sebastian Clauss
• 
  Impact of tachypacing and mechanical load on fibroinflammatory cross-talk between cardiomyocytes and non-myocytes in engineered heart tissue

  Tandy Meier

5/14 (Wed) 8:15-10:15 201+202

International Symposium 17
Mechanisms of cardiac dysfunction in diabetic heart disease

Chair

Anupam Mittal, Charles Steenbergen

• 
  Cardiomyocyte myofilament glycation in diabetes

  Jonathan Kirk
• 
  Mitophagy & the diabetic heart

  Junichi Sadoshima
• 
  Glycophagy and glycogen in diabetic cardiomyopathy

  Kim Mellor
• 
  Multi-omics approaches to investigating diabetic cardiomyopathy

  Melanie White
• 
  Metabolite-mediated PTM’s driving Diabetic Cardiomyopathy

  Lisa Heather
• 
  Neutrophil Elastase: A Novel Therapeutic Target for Heart Failure with Preserved Ejection Fraction

  Qingzhong Xiao

5/14 (Wed) 8:15-10:15 203

International Symposium 18
Cutting-edge research on genomics and omics

Chair

Fadi Charchar, Emily Wong

• 
  Non-coding RNAs as epigenetic markers of myocardial diseases

  Gianluigi Condorelli
• 
  Genome and omics analyses in CVDs

  Roger Foo
• awaiting
  Single-cell and spatial omics analysis to develop cardiovascular precision medicine

  Seitaro Nomura
• 
  Cardiotropic AAV variants

  Eddy Kizana
• 
  Transcriptional Regulation of Cardiomyocyte Polyploidization

  Miguel Torres
• 
  Genetic Landscape and Prognostic Factors in Pediatric Mitochondrial Cardiomyopathy: A 20-Year Comprehensive Study

  Atsuko Okazaki

5/14 (Wed) 14:00-16:00 A+B

International Symposium 19
Current status of cardiac regeneration therapy: from preclinical study to clinical trial

Chair

Jop Van Berlo, Kaoru Ito

• 
  Current status of human iPS cell derived cardiomyocyte transplantation to the patients with severe heart failure due to ischemic heart disease in LAPiS study

  Keiichi Fukuda
• 
  iPS-cell derived engineered heart muscle in patients with advanced heart failure

  Wolfram-H Zimmermann
• 
  Nucleotide and lipid dynamics in postnatal regeneration and stress response

  Wataru Kimura
• 
  Can Academics Make a Stem Cell Drug?

  Charles Murry
• 
  Novel Molecular Targets for Cardiac Repair in Post-Infarcted Heart

  Monika Gladka
• 
  A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

  Zhan Chen

5/14 (Wed) 14:00-16:00 201+202

International Symposium 20
Metabolic reprogramming to prevent and treat heart failure

Chair

John Elrod, Dunja Aksentijevic

• 
  Understanding Human Cardiac Metabolism

  Zoltan Arany
• 
  BCAA metabolism and HFpEF

  Tao Li
• 
  Modulating Cardiac Mitochondria with Micropeptides

  Cat Makerewich
• 
  Targeting Metabolic Maturation in the Developing and Diseased Heart

  Daniel Kelly
• 
  Omid Rouzbehani

5/14 (Wed) 14:00-16:00 203

International Symposium 21
Sex matters in Cardiovascular Metabolism

Chair

Eiki Takimoto, Cuello Friederike

• 
  Proteomic Atlas of Atherosclerosis

  Manuel Mayr
• 
  Sex differences in a newly identified heart failure syndrome

  Dhandapany Perundurai
• 
  Takotsubo Syndrome-mechanisms and Therapy

  Katrin Streckfuss-boemeke
• 
  Sex differences in diabetic-related cardiovascular disease: insights from basic science

  John Ussher
• 
  Genetic dissection of mitochondrial dysfunction in heart failure

  Yang Cao
• 
  BCAA Catabolism Targeted Therapy

  Meng Wang

5/14 (Wed) 16:15-18:15 A+B

International Symposium 22
Epigenetic Regulation of Cardiac Stress

Chair

Elena Aisha Binti Azizan, Wei Kong

• 
  Histone variants as mechanical stress sensors

  Thomas Vondriska
• 
  Epigenetic insights into cardiac biology and disease

  Liming Pei
• 
  Epigenetic regulation of direct cardiac reprogramming

  Li Qian
• 
  New insights into the pathogenic mechanism of cardiac laminopathies and the therapeutic effect of LINC complex disruption

  Jan Lammerding
• 
  Epigenetics in cardiovascular health and disease

  Sam El-Osta
• 
  Validating functional cardiomyocyte-specific histone-acetylated variant enhancers in human ES-derived cardiomyocytes using a STARR-Seq Approach

  Chang Jie Mick Lee

5/14 (Wed) 16:15-18:15 201+202

International Symposium 23
Cardiac Ca2+ handling as a therapeutic target

Chair

Davor Pavlovich, Cecilia Mundina

• 
  Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease.

  Eduardo Bertero
• 
  The Ca2+-sensitive protein Dysferlin protects cardiomyocyte nanodomains in ischemic heart disease

  Stephan Lehnart
• 
  Assembly and disassembly of cardiomyocyte structure during development and disease.

  Manfra Ornella
• 
  Impaired intracellular buffering as arrhythmogenic substrate in cardiomyocytes from patients with Afib

  Niels Voigt
• 
  Modulation of Sarcoplasmic Reticulum Ca2+ release and uptake: focus on the Ca2+ waves and Ca2+ alternans relationship

  Luis Gonano
• 
  Pathological impact of SARS-CoV-2 viroporin on the cardiomyocyte function

  Jin O'Uchi

5/14 (Wed) 16:15-18:15 203

International Symposium 24
Mediators of protein phosphorylation in cardiac disease

Chair

Satomi Akahane, Huangtian Yang

• 
  Role of TRPM4 in Cardiac Disease and Arrhythmogenesis

  Maria Kontaridis
• 
  Interleukin-6 signaling as an upstream mediator of altered RyR2 phosphorylation in post-operative atrial fibrillation

  Xander Wehrens
• 
  Beta-adrenergic regulation of cardiac function through PI3K signaling

  Alessandra Ghigo
• 
  The cardiac phosphatome in metabolic heart disease & failure

  Kate Weeks
• 
  PHLPPs in cardiac physiology & pathophysiology

  Nicole Purcell
• 
  AKAP1 silencing-based gene therapy for the prevention of cardiac hypertrophy

  Hariharan Subramanian