Japan Section

5/12 (Mon) 8:30-10:30 205+206

Japan Section 1
Advances in research for cardiovascular aging

Chair

Naoki Mochizuki, Toru Minamino

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  Modulation of Age-related Epigenome via In Vivo Reprogramming

  Yasuhiro Yamada
• 
  Wnt signaling regulates a unique fibroblast subpopulation to modulate cardiac fibrosis

  Bin Zhou
• 
  Unraveling the links: Cardiovascular disease and aging.

  Ippei Shimizu
• 
  Clonal hematopoiesis: The hidden mechanism underlying cardiovascular disease

  Yoshimitsu Yura
• 
  Aging and inflammatory signaling in heart disease

  Yasutomo Higashikuni
• 
  Roles and Mechanisms of Cellular Senescence in Aging-Associated Diseases: Insights into Microbial Interactions

  Eiji Hara

5/12 (Mon) 16:05-18:05 205+206

Japan Section 2
A novel spontaneous atrial fibrillation mouse model unveils fibrotic remodeling

Chair

Lan Hieu Nguyen, Masaki Ieda

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  Multifaceted Role of Cereblon in Heart Failure: From Metabolism to Ion Channel Regulation

  Hyoung Kyu Kim
• 
  Epigenetic and post-translational control of cardiac remodeling in heart failure

  Adam Wende
• 
  Single-Cell Analysis Reveals Fibroblast-Cardiomyocyte Crosstalk in the Development of Heart Failure: Mechanism and Therapeutic Opportunity

  Toshiyuki Ko
• 
  Therapeutic targets and circulating biomarkers for right ventricular failure and fibrosis in pulmonary hypertension

  Tetsuro Yokokawa
• 
  Therapeutic Perspectives on Fibrosis-Associated Cardiac Diseases

  Chun-han Chang
• 
  Immuno-modulatory signaling between cardiac fibroblasts and macrophages mediated by COX2.

  Matt Ackers-Johnson

5/13 (Tue) 8:15-10:15 205+206

Japan Section 3
Interorgan Cross-talk in Cardiovascular Health and Disease

Chair

Yuichi Oike, Satoaki Matoba

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  Structural Instability of Type 2 Ryanodine Receptors on Endoplasmic Reticulum (ER) Membrane Causes ER Stress-Related Diseases in Various Organs

  Hitoshi Uchinoumi
• 
  TBD

  Katsuhito Fujiu
• 
  The Brain as a Central Hub of Neural Interorgan Cross-talk in Hypertension and Heart Failure

  Keisuke Shinohara
• 
  Decoding the Function of GPR75 in Obesity and Progressing Toward Antagonist-Based Therapies

  Haojie Yu
• 
  CNOT6L-Mediated Deadenylation in Cardiac Stress: A Protective Mechanism with Systemic Implications

  Teruki Sato
• 
  Metabolic Mechanisms of Heart Failure and Targeted Therapies

  Yibin Wang

5/13 (Tue) 14:50-16:50 205+206

Japan Section 4
Novel insights into pulmonary hypertension and right ventricular dysfunction

Chair

Kotaro Abe, Koji Maemura

• 
  Activation of aryl hydrocarbon receptor via gut microbiota alterations in the pathogenesis of pulmonary hypertension

  Yoshikazu Nakaoka
• 
  Activin-A as a Novel Upstream Driver of Vascular Remodeling and Endothelin-1 Signaling in Pulmonary Arterial Hypertension

  Noriaki Emoto
• 
  Prognosis and Risk of RV Dysfunction in Adult Pulmonary Hypertension Related to Congenital Heart Disease

  Dyah Wulan Anggrahini
• 
  Elucidation of the pathophysiology of pulmonary arterial hypertension using a three-dimensional imaging system

  Norifumi Takeda
• 
  Pulmonary arterial hypertension in Japan, focusing on the pathogenetic gene variants in BMPR2 and RNF213 genes

  Takahiro Hiraide
• 
  Mechanistic Role of RyR2 Stabilization in Maintaining Right Ventricular Myocardial Function

  Takeshi Suetomi

5/13 (Tue) 17:05-19:05 205+206

Japan Section 5
Young Investigator Award

Chair

Yasuchika Takeishi,Koji Maemura

• 
  Histone serotonylation as a novel cardioprotective epigenetic mechanism in HFpEF

  Ryo Ogawara
• 
  Prime editing correction of an Nkx2-5 variant in a murine congenital heart disease model

  Daigo Nishijo
• 
  The mechanism by which Asxl1 clonal hematopoiesis promotes inflammation and exacerbates heart failure

  Akito Shindo
• 
  Single-Cell Multi-Omics Analysis Reveals Mechanisms of Aerobic Exercise-Mediated Cardioprotection in Ischemic Cardiomyopathy

  Takahiro Jimba
• 
  Disruption of the Golgi apparatus exerts ER stress, mitochondrial dysfunction, and cardiac remodeling and dysfunction via CDK5-Golgi stress response pathway

  Wataru Otsuru

5/14 (Wed) 8:15-10:15 205+206

Japan Section 6
Innate and Adaptive Immune Responses in Cardiovascular Disease

Chair

Motoaki Sano, Toyoaki Murohara

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  Disruption of multi-organ homeostasis in lifestyle diseases caused by SPP1-producing macrophages

  Kosuke Shirakawa
• 
  Deciphering fibroblast-immune axis identifies a novel mechanism underlying postinfarction cardiac repair

  Atsushi Anzai
• 
  The Efferocytosis-Endoplasmic Reticulum Stress Loop Governs Immune Responses and Heart Failure in Cardiac Ischemic Diseases

  Xiaoxiang Yan
• 
  TLR7 in cardiac injury

  Jiong-Wei Wang
• 
  The regulatory mechanisms of inflammasome activation and neutrophil infiltration in atherosclerosis

  Tadayoshi Karasawa
• 
  Spatial Multi-omics Analysis of Immune Cell Dynamics in Cardiac Sarcoidosis

  Mikako Katagiri

5/14 (Wed) 14:00-16:00 205+206

Japan Section 7
Novel mechanisms in arrhythmogenesis

Chair

Takanori Yamaguchi, Shigeki Kobayashi

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  Epicardial Adipose Tissue and Atrial Fibrillation

  Naohiko Takahashi
• 
  Histopathological Evaluation of Atrial Fibrillation: Insights from 1,000 Atrial Biopsy Cases

  Takanori Yamaguchi
• 
  Mitochondrial dynamics and cardiac arrhythmias

  Nipon Chattipakorn
• 
  Familial Sinus Node Dysfunction Caused by an Intergenic Deletion between PITX2 and ANK2: Analysis Using a Human iPSC-derived Sinoatrial Node Model

  Takeru Makiyama
• 
  Upstream partial blockade of the cardiac sympathetic afferent system to suppress β adrenergic signaling for the antiarrhythmic effect

  Koji Yoshie
• 
  Genetic backgrounds and pathogenesis of inherited arrhythmia syndromes in Japan

  Seiko Ohno

5/14 (Wed) 16:15-18:15 205+206

Japan Section 8
Updates on Onco-cardiology: molecular mechanisms and therapeutic approaches

Chair

Hiroshi Akazawa, Yasuchika Takeishi

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  Pilot Study Investigating KCNJ5 Somatic Mutations Role on Cardiovascular Outcomes Among Malaysian Primary Aldosteronism Patients

  Elena Azizan
• 
  Ferroptosis in Anthracycline-Induced Cardiotoxicity-From Mechanistic Insights to a Novel Preventive Strategy-

  Masataka Ikeda
• 
  Clonal hematopoiesis and cardiovascular disease: pathological role of JAK2 mutations in Onco-Cardiology

  Tomofumi Misaka
• 
  A Pilot Study Exploring Autoantibody Signatures in Patients with Immune Checkpoint Inhibitor-Induced Myocarditis

  Kazuko Tajiri
• 
  Ryanodine Receptor as a Pharmacological Target to Prevent Doxorubicin-induced Cardiomyopathy

  Yoshihide Nakamura
• 
  Onco-Cardiology/Cardio-Oncology as a novel platform of cardiovascular research

  Toru Oka