Speakers
Keynote Lecture
Symposium
Cardiac Ca2+ handling as a therapeutic target
- Chair
- Cecilia Mundina, Davor Pavlovich
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Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease.Eduardo Bertero
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Modulation of Sarcoplasmic Reticulum Ca2+ release and uptake: focus on the Ca2+ waves and Ca2+ alternans relationshipLuis Gonano
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awaitingCa2+-binding ferlin protein expression improves left-ventricular function post-myocardial infarctionStephan Lehnart
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Developmental and Sex-dependent particularities of cardiac Ca2+ handling and its therapeutic relevanceWilliam (Bill) Louch
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Impaired intracellular buffering as arrhythmogenic substrate in cardiomyocytes from patients with AfibNiels Voigt
Cardiac Hippo-YAP signaling
- Chair
- Metin Avkiran, Emilio Hirsch
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The role of YAP in cardiac fibrosisDominic Del Re
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Targeting Hippo-YAP signaling in heart failureJames Martin
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Role of Hippo-YAP in cardiac development and regenerationEnzo Porrello
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awaitingWnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytesIchiro Shiojima
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awaitingBeta adrenergic and YAP crosstalk regulate cardiomyocyte proliferationMei Xin
Current status of cardiac regeneration therapy: from preclinical study to clinical trial
- Chair
- Kaoru Ito, Jop Van Berlo
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Current status of human iPS cell derived cardiomyocyte transplantation to the patients with severe heart failure due to ischemic heart disease in LAPiS studyKeiichi Fukuda
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Harnessing gene therapies to enhance vessel formation and cardiac repairMonika Gladka
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Nucleotide and lipid dynamics in postnatal regeneration and stress responseWataru Kimura
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awaitingCan Academics Make a Stem Cell Drug?Charles Murry
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awaitingiPS-cell derived engineered heart muscle in patients with advanced heart failureWolfram-H Zimmermann
Cutting-edge research on genomics and omics
- Chair
- Fadi Charchar, Emily Wong
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Non-coding RNAs as epigenetic markers of myocardial diseasesGianluigi Condorelli
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Genome and omics analyses in CVDsRoger Foo
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Cardiotropic AAV variantsEddy Kizana
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awaitingSingle-cell and spatial omics analysis to develop cardiovascular precision medicineSeitaro Nomura
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awaitingPluripotency, Competition and Heart RegenerationMiguel Torres
Drug targets in Heart Failure
- Chair
- Walter J Koch, Lauren May
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Development of genome editing tools based on deep mutational scanningAtsushi Hoshino
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Targeting CAMKII to mend the failing heartSimon Lebek
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HDACs as target for therapy in heart failureTim McKinsey
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GRK2 and Cardio-metabolic signaling in Heart FailurePriscila Sato
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Treating heart failure with novel REV-ERB agonistLilei Zhang
E-C Coupling: channels, regulators and key players
- Chair
- Ana-Maria Gomez, Yoshihiko Saito
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S-Nitrosylation of CaMKII and cardiac arrhythmiaJeffrey Erikson
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Mechanisms of mitochondrial morphology changes in RyR2 mutation-associated CPVTShanna Hamilton
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Rad regulation of cardiac calcium channels and cardiac contractilitySteven Marx
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Junctophilin-2 Regulation of Cardiac E-C Coupling and TranscriptionLong-Sheng Song
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GRK2 regulation of beta-adrenergic signaling and Ca2+ handling in the heartShi-Qiang Wang
Epigenetic Regulation of Cardiac Stress
- Chair
- Wei Kong, Koichiro Kuwahara
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awaitingEpigenetics in cardiovascular health and diseaseSam El-Osta
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New insights into the pathogenic mechanism of cardiac laminopathies and the therapeutic effect of LINC complex disruptionJan Lammerding
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Epigenetic insights into cardiac biology and diseaseLiming Pei
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Epigenetic regulation of direct cardiac reprogrammingLi Qian
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Histone variants as mechanical stress sensorsThomas Vondriska
Health and Disease Mechanisms of Women’s Heart
- Chair
- Lorrie Kirshenbaum
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Sex differences in cardiac electrophysiology and drug responseRaffaele Coppini
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Heart failure with preserved ejection fraction in humans and mice: what does sex have to do with it?Rudolf de Boer
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Cardiac sex-age interactions and proteogenomic insightsMaggie Lam
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The cardiac pathophysiological outcomes of shift work during pregnancyInna Rabinovich-Nikitin
Interorgan communications in heart failure
- Chair
- Doan Ngo, KK Talwar
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Brain-heart cross talk in HFDaniela Carnevale
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awaitingHematopoietic mutations and cardiac fibrosisStefanie Dimmeler
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Multi-organ cross-talk in heart failureYukiteru Nakayama
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Liver/adipose tissue-Heart cross talk in HFpEF and Cardiometabolic diseaseGabriele Schiattarella
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Immune checkpoint signaling and heart failureZoltan Varga
Mechanisms of cardiac dysfunction in diabetic heart disease
- Chair
- Charles Steenbergen
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Cardiac metabolic remodeling in diabetesLisa Heather
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Cardiomyocyte myofilament glycation in diabetesJonathan Kirk
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Glycophagy and glycogen in diabetic cardiomyopathyKim Mellor
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awaitingMitophagy & the diabetic heartJunichi Sadoshima
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Multi-omics approaches to investigating diabetic cardiomyopathyMelanie White
Mechanistic insights of the role of impaired cardiac metabolism in driving heart failure
- Chair
- Yasuchika Takeishi, Junjie Xiao
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awaitingMitochondrial crystae dynamics in the aging heartVeronica Eisner
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Mechano-energetic uncoupling in HFrEF and HFpEFChristoph Maack
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awaitingIdentification of new transcription factors involved in the control of cardiac hypertrophy and mitochondrial metabolism of cardiomyocytesValentina Parra
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New mechanistic insights into cardiac fibrosis and heart failure in diabetes emerging from cutting-edge computational biology and single-cell omicsAlexander Pinto
Mediators of protein phosphorylation in cardiac disease
- Chair
- Satomi Adachi-Akahane, Zijian Li
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Beta-adrenergic regulation of cardiac function through PI3K signalingAlessandra Ghigo
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Role of TRPM4 in Cardiac Disease and ArrhythmogenesisMaria Kontaridis
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PHLPPs in cardiac physiology & pathophysiologyNicole Purcell
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awaitingThe cardiac phosphatome in metabolic heart disease & failureKate Weeks
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PP1 isoform-specific regulation of cardiac arrhythmiasXander Wehrens
Metabolic reprogramming to prevent and treat heart failure
- Chair
- John Elrod, Issei Komuro
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Understanding Human Cardiac MetabolismZoltan Arany
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Targeting Metabolic Maturation in the Developing and Diseased HeartDaniel Kelly
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BCAA metabolism and HFpEFTao Li
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Modulating Cardiac Mitochondria with MicropeptidesCat Makerewich
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Mitochondrial Transfer: a Therapy for Cardiomyopathy?Aijun Sun
Mitochondria, Protein homeostasis and Cell Death
- Chair
- Tish Murphy, Kinya Otsu
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Extracellular Vesicles and Cellular Quality Control Mechanisms in CardioprotectionAsa Gustafsson
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Role of lipid phosphate phosphatases in cardiac energy metabolism and functionPetra Kienesberger
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awaitingCross-Talk between Ferroptosis and NecroptosisRichard Kitsis
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Mitochondrial Shape, Autophagy, and Heart Failure: a Triad to Combat.Luca Scorrano
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Targeting the JAK1-STAT3 pathway to treat cardiac proteinopathySonia Singh
Modulators of cell-cell communication in heart failure
- Chair
- Pilar Alcaide, Susmita Sahoo
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Macrophages as protectors of mitochondrial quality in the heart and beyondJose Angel Nicolas Avila
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Innate immune memory and organ cross-talk in heart failureIchiro Manabe
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Impact of heart-derived factors from the protected and failing heartJulie McMullen
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Exercise-induced interorgan communicationKristin Stanford
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Organ cross-talk during heart failureThomas Thum
New mechanisms to protect against heart failure with preserved ejection fraction
- Chair
- David Lefer, Emiliano Medei
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awaitingTargeting Class IIa HDAC signaling in cardiometabolic diseaseJohannes Backs
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Tyrosine kinase phosphorylation of troponin I is a novel mechanism to increase myocardial relaxationBrandon Biesiadecki
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awaitingUnique immunometabolic treatment strategies to protect against HFpEFJudy de Haan
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Cyclic GMP as a therapeutic target for HFpEFRebecca Ritchie
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Trans-differentiation of cardiac fibroblasts reveals a new molecular mechanisms for HfpEFTaketaro Sadahiro
New players in mitochondrial calcium regulation
- Chair
- Lea Delbridge, Yi Zhu
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TMEM65 controls mitochondrial Ca2+ extrusionDiego De Stefani
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Communication between LTCC and the mitochondriaLivia Hool
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Targeting mitochondrial ROS formation in cardiac pathologyNina Kaludercic
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Sarcoplasmic reticulum-mitochondria communication in diabetic HFpEFMelanie Paillard
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A new facet of myocardial necroptosis: crosstalk with mitochondrial dynamics and autophagyToshiyuki Yano
Non-Myocyte Contributors to Arrhythmia
- Chair
- Bianca Brundel, Zully Pedrozo
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Cardiac adiposity and arrhythmiasJim Bell
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Fibroblast-Myocyte interactions and their impact on cardiac electrophysiologyPatrizia Camelliti
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Macrophages and Electrical conduction in the HeartSebastian Clauss
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Fibroblasts regulate cardiac excitability and arrhythmogenesisArjun Deb
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Exploring the role of neuronal dysfunction in inherited arrhythmia syndromesMolly O'Reilly
Regulation of endogenous cardiac regeneration
- Chair
- Alejandro Orlowski, Florian Weinberger
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RNA therapies for cardiac regenerationMauro Giacca
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A switch in cardiac fibroblasts hinders regeneration after neonatal myocardial infarctionDiana Nascimento
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Modulating cell polarity and cytoarchitecture to promote cardiomyocyte regenerationCaitlin C. O'Meara
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Advancing Cardiac TherapeuticsEldad Tzahor
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Creating a repair permissive heartEva van Rooij
Regulatory mechanisms of intracellular Ca2+ signalling and excitability via intracellular organelle cross-talk
- Chair
- Michelle Munro
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Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in ARVCMario Delmar
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Critical role of NRSF-GNAO1 pathway in regulating Ca2+ signaling in ventricular myocytesHideaki Inazumi
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RyR2 as an antiarrhythmic drug targetBjorn C. Knollmann
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Impact of Ca2+ crosstalk between mitochondria and sarcoplasmic reticulum in cardiomyocyte during workload transitionAyako Takeuchi
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Critical role of mitochondrial remodeling in cardiac arrhythmiaDeli Zhang
Sex matters in Cardiovascular Metabolism
- Chair
- Friederike Cuello, Eiki Takimoto
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Genetic dissection of mitochondrial dysfunction in heart failureYang Cao
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Proteomic Atlas of AtherosclerosisManuel Mayr
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awaitingSex differences in a newly identified heart failure syndromeDhandapany Perundurai
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awaitingTakotsubo Syndrome-mechanisms and TherapyKatrin Streckfuss-boemeke
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Sex differences in diabetic-related cardiovascular disease: insights from basic scienceJohn Ussher
Shaping the cardiac proteome in health and disease
- Chair
- Lucie Carrier, Ying Ge
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RNA binding proteins in stress responsive gene regulationFederica Accornero
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awaitingThe unfolded protein response and ER stressShirin Doroudgar
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Proteostasis in hypertrophic cardiomyopathyDiederik Kuster
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Myosin S2 and cMyBP-C Interactions in Cardiac Function and Hypertrophic CardiomyopathySakthivel Sadayappan
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Regulation of the cardiac translatomeYibin Wang
Spatial organization of protein synthesis in the myocardium
- Chair
- Tim Kamp, Llewelyn Roderick
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Beta 1 and beta 2 receptor translation dynamics in healthy and failing heartJulia Gorelik
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Localized protein translation in the heartIzhak Kehat
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The tubulin code as spatial regulator - what can we learn from the brain?Marie-Jo Moutin
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Microtubule-mediated spatial control: directing translation and remodeling in the myocardiumBenjamin L. Prosser
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Coordinated cotranslational association of ion channels mRNA in the heartGail A. Robertson
Targeting metabolism to prevent heart failure progression: HFrEF vs HFpEF
- Chair
- Derek Hausenloy, Yumiko Oishi
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Targeting nicotinamide adenine dinucleotide for the treatment of HFpEFMahmoud Abdellatif
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Targeting glucose-derived O-GlcNAcylation pathway in heart failureLuc Bertrand
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Mitochondria in HFpEFRong Tian
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awaitingMyocardial proteome defines the continuum in human HFpEFJenny van Eyk
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The protective role of exercise on children metabolic syndromeMing Xu
Awardee Lecture
Peter Harris Distinguished Scientist Award
Research Achievement Award
Outstanding Investigator Award
Keith Reimer Distinguished Lecture Award
Janice Pfeffer Distinguished Lecture Award
President's Distinguished Lecture Award
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awaitingAlcaide Pilar